【论著】幽门螺杆菌抗体谱组分类型与妊娠剧吐反应的相关性研究

  09-06- 12  

摘要目的通过生物芯片对孕妇血清进行幽门螺杆菌(Hp)抗体谱分型，探讨Hp感染抗体谱与妊娠剧吐的相关性。方法病例对照法，采用幽门螺杆菌抗体谱检测蛋白芯片分析，一次检测Hp的多种血清学标志CagA、VacA、Ure、 Hsp60等抗体。结果研究组Hp阳性率90%，对照组60%。CagA+Hp、VacA+Hp、Hsp60+Hp三种中至少一项毒力株感染率研究组为83.3%、对照组为30%。结论妊娠剧吐与HP感染抗体谱分型中CagA+型、VacA型显著相关，同时HP感染与O型血孕妇更为相关。
关键词幽门螺杆菌抗体谱妊娠剧吐相关研究
Study on relationship between antibody spectrum of Helicobacter pylori  with Hyperemesis gravidarum
LI Jun1XU YuanfengTIE Hongli
ABSTRACTObjectiveTo explore the relationship of spectral types of Hp antibodies repertoire with hyperemesis gravidarum. Through biochip with maternal serum, the Helicobacter pylori (Hp) antibody spectral types were determined. MethodsUsing Helicobacter pylori antibody proteinchip, we can detect various antibodies of Hp serum markers at one time. Those Hp serum markers include CagA, VacA, Ure, Hsp60 etc. ResultsPositive rate of Hp is 90% in test group and 60% in control group. Meanwhile, The total positive rate of either CagA+Hp, Vac+Hp, or Hsp60+Hp is 83.3% in test group, but 30% in the control.ConclusionsThis study showed that HPCagA infection and HPVacA infection are correlated with hyperemesis gravidarum, and more related significance to pregnant women with serum group O.
KEY WORDSAntibody spectrum of Helicobacter pyloriHyperemesis gravidarumCorrelation study

作者单位1. 陕西中医学院体质与疾病遗传基础研究室
2. 深圳欣康基因数码科技有限公司
3. 陕西咸阳计生委科技科