【综述】XPC基因Ala499Val 和 Lys939Gln多态与癌症发病风险关联的meta分析

  08-10-21  

张佳鑫 钟逾 邵敏华 钱吉范 薇薇 卢大儒
摘要目 的为更清楚地了解NER通路上的XPC基因多态性与癌症发病风险的关联。方法利用所有已发表的相关病例 对照研究对两个重要单核苷酸多态性位点：Ala499Val 和Lys939Gln进行了meta 分析。结果Ala499Val位点的总体分析发现，499TT基因型的个体比499CT及499CC基因型个体，其癌症发病风险高25％(OR = 1.25, 95% CI =1.09?1.44)；499CT杂合基因型个体的癌症发病风险较纯合基因型个体低10% (OR = 0.90, 95%CI = 0.84?0.97)。Lys939Gln位点的总体分析发现，939CC基因型的个体比939CA与939AA基因型个体的癌症发病风险略高8% (OR = 1.08, 95%CI = 1.00 1.16)。此外，依据癌症种类和人群的不同对两个位点的亚组分析结果发现，Lys939Gln位点在高加索人群中与癌症发病风险显著相关。结论499T和939C均为风险性的等位基因。499TT或939CC基因型的个体、尤其是939CC基因型的高加索人，有更高的癌症发生的可能性。
关键词meta分析XPCSNP癌症风险
The association of XPC Ala499Val and Lys939Gln polymorphisms with cancer risk: a meta analysis
ZHANG Jia?xinZHONG YuSHAO Min huaQIAN JiFAN Wei?weiLU Da?ru
ABSTRACTObjective and MethodsIn order to clarify the association between the two polymorphisms：Ala499Val and Lys939Gln in XPC in NER pathway and cancer risk, we performed a meta analysis from all eligible case?control studies. ResultsThe results showed that individuals with the 499TT genotype showed a 25% (OR = 1.25, 95% confidence interval (CI) = 1.09?1.44) increased cancer risk compared with individuals with the 499CT/499CC genotype; On the other hand, individuals with the 499CT genotype was associated with a 10% (OR = 0.90, 95%CI = 0.84?0.97) decreased cancer risk. The results also showed that individuals with the 939CC (10104 cancer patients and 12 652 controls) associated with a 8% (OR = 1.08, 95%CI = 1.00?1.16) increased cancer risk compared with CA + AA genotypes. We also performed two subgroup according to cancer type and ethnicity, and there was a significant increased cancer risk in Caucasian descent associated with the Lys939Gln polymorphism. ConclusionThese results support the hypothesis that both 499T and 939C alleles are risk allele for cancer, and individuals with 499TT or 939CC genotype, especially Caucasians with 939CC, have higher risk of cancer development.
KEY WORDSMeta analysisXPCSNPCancer risk